Detalhe da pesquisa
1.
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway.
Cell
; 186(11): 2361-2379.e25, 2023 05 25.
Artigo
Inglês
| MEDLINE | ID: mdl-37192619
2.
Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.
Immunity
; 56(11): 2523-2541.e8, 2023 Nov 14.
Artigo
Inglês
| MEDLINE | ID: mdl-37924812
3.
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Cell
; 171(3): 696-709.e23, 2017 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-28965760
4.
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Cell
; 150(6): 1196-208, 2012 Sep 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22980980
5.
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Cell
; 141(2): 290-303, 2010 Apr 16.
Artigo
Inglês
| MEDLINE | ID: mdl-20381137
6.
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation.
Proc Natl Acad Sci U S A
; 117(12): 6571-6579, 2020 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-32156728
7.
SnapShot: mTORC1 signaling at the lysosomal surface.
Cell
; 151(6): 1390-1390.e1, 2012 Dec 07.
Artigo
Inglês
| MEDLINE | ID: mdl-23217718
8.
Lysosome: The metabolic signaling hub.
Traffic
; 20(1): 27-38, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30306667
9.
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Nat Chem Biol
; 15(5): 453-462, 2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30911178
10.
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.
Mol Cell
; 52(4): 495-505, 2013 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-24095279
11.
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease.
Biochemistry
; 59(19): 1793-1799, 2020 05 19.
Artigo
Inglês
| MEDLINE | ID: mdl-32364701
12.
Chemical proteomics to study metabolism, a reductionist approach applied at the systems level.
Cell Chem Biol
; 31(3): 446-451, 2024 Mar 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38518745
13.
Reductive stress in cancer: coming out of the shadows.
Trends Cancer
; 10(2): 103-112, 2024 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37925319
14.
Chemical biology approaches to uncovering nuclear ROS control.
Curr Opin Chem Biol
; 76: 102352, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37352605
15.
The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer.
Cancer Drug Resist
; 6(2): 345-357, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-37457127
16.
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Cell Metab
; 35(3): 487-503.e7, 2023 03 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36841242
17.
Identification of chemotherapy targets reveals a nucleus-to-mitochondria ROS sensing pathway.
bioRxiv
; 2023 Mar 11.
Artigo
Inglês
| MEDLINE | ID: mdl-36945474
18.
Principles and functions of metabolic compartmentalization.
Nat Metab
; 4(10): 1232-1244, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36266543
19.
Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS-MAPK Reactivation.
Cancer Discov
; 11(8): 1913-1922, 2021 08.
Artigo
Inglês
| MEDLINE | ID: mdl-33824136
20.
How Sweet It Is: Small-Molecule Inhibitors of mTORC1 Glucose Sensing.
Cell Chem Biol
; 26(9): 1195-1196, 2019 09 19.
Artigo
Inglês
| MEDLINE | ID: mdl-31539502